Bioidentical Progesterone Therapy for Women

Restore calm, sleep, and strength
Progesterone helps you feel calm, balanced, and deeply rested. As levels begin to decline in your mid-30s, often years before menopause, subtle but frustrating changes can start to show up.

Restore calm, sleep, and clear thinking

Fall asleep faster and wake up feeling rested.

Clear brain fog and feel restored energy.

Ease anxiety and smooth mood swings.

Reduce bloating and breast tenderness.

Fall asleep faster and wake up feeling rested.

Ease anxiety and smooth mood swings.

Clear brain fog and feel restored energy.

Reduce bloating and breast tenderness.

What is bioidentical progesterone therapy?

Progesterone is the hormone that helps your body relax, sleep, and prepare for each menstrual cycle. It’s also critical for maintaining uterine health, supporting metabolism, and working in harmony with estrogen.

Bioidentical progesterone is molecularly identical to the hormone your body naturally produces. Unlike synthetic progestins (commonly used in birth control or older hormone therapies), bioidentical progesterone behaves exactly like your own, without the unwanted side effects linked to synthetic versions.

When prescribed and monitored by a licensed Fem Excel provider, bioidentical progesterone therapy is:

Clinically supported: Backed by peer-reviewed medical research
Personalized: Dosed according to your unique hormone levels
Safe and effective: Especially when used as part of a complete hormone optimization plan

Bioidentical progesterone treatment options

At Fem Excel, your treatment plan is customized based on your symptoms, lab results, and lifestyle. We don’t follow a “one-size-fits-all” or cycling protocol. Your care is built for you.

Oral Capsules (Micronized Progesterone): Taken nightly, oral progesterone supports deep, restorative sleep while protecting the uterine lining.
Topical Cream: Applied to the skin, topical progesterone allows for smooth, steady absorption and symptom relief.
Vaginal Suppositories (As Prescribed): Used when targeted, localized delivery is needed for uterine or vaginal support.

Benefits of bioidentical progesterone therapy

Better sleep

Promotes relaxation and helps you fall, and stay asleep naturally.

Calmer mood

Activates GABA receptors in the brain, the body’s primary calming pathway. This helps reduce anxiety, promote relaxation, and stabilize emotional swings.

Smoother cycles

Helps regulate periods, lighten heavy bleeding, and reduce PMS symptoms.

Fewer hot flashes

Works synergistically with estrogen therapy to reduce temperature fluctuations.

Sharper focus

Improves concentration, energy, and mental clarity throughout the day.

How it works

Our in-house team specializes in hormone optimization and takes the time to understand your symptoms, goals, and history. Doctor-led hormone therapy is the key to real symptom relief, healthy aging, and results that last.

Start with your story.
Share your symptoms and health history through our online assessment.

Meet your hormone expert.
Connect online with a licensed provider to discuss your symptoms and goals. If prescribed, treatment can start right away.

Get deeper insights.
After your consult, we’ll send you a simple at-home hormone test kit to measure key biomarkers and fine-tune your care.

Personalized, ongoing support. 
Once your lab results are in, your provider will review your progress and adjust your treatment as needed. We check in every 60 days, and you’ll receive comprehensive blood tests every six months to keep your care truly personalized. 

Thousands of women are already experiencing the benefits.
Start your free assessment today.

85%

report improvement within 2 months*

96%

report improvement within 6 months*

100,000+ patients treated*

Among America’s fastest-growing companies. Voted Top Hormone Provider of 2024 and Hormone Provider of the Year 2025.

^*Data taken from 32,795 members responding to symptoms reviews with their Excel Medical providers

“Many women come to us feeling flat, exhausted, and disconnected from themselves. They’re doing all the right things, yet still don’t feel like them anymore. All too often, no one has ever talked to them about testosterone.

I’ve seen testosterone change women’s lives. Energy comes back. Motivation returns. Libido wakes up. They start engaging with life again.”

Lorna A. Brudie, DO, FACOG, FACOOG
Medical Director

Lorna A. Brudie, DO, FACOG, FACOOG 
Medical Director

What our patients say

When your hormones are off, everything feels harder. But with the right care and optimized hormones, everything changes.

Women come to Fem Excel feeling tired, foggy, frustrated, and unheard. They stay because they feel energized, clear-minded, unburdened, and back in control.

These are their stories, not just of better health, but of lives transformed.

Very knowledgeable & professional

“Very knowledgeable & professional. Details about the whole process and the medications that I may be taking. I was very happy to have a caring one on one with the NP. It is the help I was waiting for in the convenience of my own quiet setting.”

Possibly the best healthcare experience I’ve ever had

“I walked away from this appointment actually feeling satisfied with the results I received. For once I left an appointment with all my questions answered instead of having more questions than answers. The provider was very thorough, informative, and helpful. This was one of the better healthcare appointments I have ever had. Thank you Ms. Tara for the wonderful experience.”

Caring and thorough

“I really liked ease and convenience having a virtual appointment. Kel made me feel comfortable immediately and explained everything thoroughly. She is a good listener and has an empathetic spirit about her. I feel encouraged that together we will resolve any challenges I am having.”

I had been struggling since I hit menopause…

“I had been struggling since I hit menopause a year ago. My doctors couldn’t help. It was terrible, I was struggling with no hope for any help. Then I tried Fem Excel. They HAVE CHANGED MY LIFE! I have energy, I sleep well I feel so good, it’s unbelievable and the doctors were so efficient and I just felt understood. I am so glad I got a hold of this company. Thank you so much!”

Real Reviews, Actor Portrayal shown

Related symptoms

Fatigue that doesn’t make sense

When rest, sleep, and caffeine don’t help, low thyroid or low progesterone could be the reason. We identify and treat the true cause to restore lasting energy.

Hormonal breast tenderness or swelling

If your breasts feel sore, heavy, or swollen before your period, it could be due to estrogen and progesterone imbalance. We restore hormonal balance to relieve discomfort and reduce monthly symptoms.

Hormonal bloating or digestive issues

If you experience bloating, gas, or changes in digestion before your period, hormone imbalance may be the cause. We rebalance estrogen and progesterone to support smoother digestion and reduce bloating.

Persistent fatigue

If you feel constantly drained, even after rest, low thyroid, testosterone, or progesterone could be the cause. We treat all three to help restore lasting energy.

Fatigue that doesn’t make sense

When rest, sleep, and caffeine don’t help, low thyroid or low progesterone could be the reason. We identify and treat the true cause to restore lasting energy.

Hormonal breast tenderness or swelling

If your breasts feel sore, heavy, or swollen before your period, it could be due to estrogen and progesterone imbalance. We restore hormonal balance to relieve discomfort and reduce monthly symptoms.

Hormonal bloating or digestive issues

Persistent fatigue

If you feel constantly drained, even after rest, low thyroid, testosterone, or progesterone could be the cause. We treat all three to help restore lasting energy.

The Excel Advantage™ membership

$99/month

Get dedicated physician support, regular monitoring, and personalized adjustments so your hormone therapy evolves with you.

In-house specialists

Trained directly in the Excel Advantage™ protocol.

Integrated treatment

Hormones, metabolic support, and advanced therapies.

Symptom-driven care

Treatment guided by symptoms, not lab numbers alone.

Member access & pricing

Access to advanced treatments with preferred pricing.

Precision monitoring

Regular labs with personalized treatment adjustments.

60-day follow-ups

Provider reviews to refine and optimize treatment.

No commitment required • Cancel anytime • Medications not included

Medically Reviewed

This page was medically reviewed by Peter Fotinos, MD, Chief Medical Officer, and Lorna A. Brudie, DO, FACOG, FACS, Medical Director, Excel Medical. Dr Fotinos and Dr Brudie have nearly 50 years of combined clinical experience in hormone optimization and preventive medicine.

Last reviewed: October 2025

References

Citations

Stuenkel CA, Davis SR, Gompel A, Lumsden MA, Murad MH, Pinkerton JV, Santen RJ. Treatment of Symptoms of the Menopause: An Endocrine Society Clinical Practice Guideline. Journal of Clinical Endocrinology & Metabolism. 2015;100(11):3975–4011. https://pubmed.ncbi.nlm.nih.gov/26444994/
Sherwin BB. Estrogen and Cognitive Functioning in Women. Endocrine Reviews. 2003;24(2):133–151. https://pubmed.ncbi.nlm.nih.gov/12700177/
Manson JE, et al. Menopausal Hormone Therapy and Health Outcomes. JAMA. 2013;310(13):1353–1368. https://jamanetwork.com/journals/jama/fullarticle/1745676
Rodrigues H, Alexandre M, Gompel A. Micronized progesterone, progestins, and menopause hormone therapy. Women & Health. 2021;61(1):3–14. https://pubmed.ncbi.nlm.nih.gov/32957843/
Lieberman A, Curtis L. In defense of progesterone: a review of the literature. Alternative Therapies in Health & Medicine. 2017;23(7):24–32. https://pubmed.ncbi.nlm.nih.gov/29055286/
Prior JC. Progesterone for Symptomatic Perimenopause Treatment: Progesterone politics, physiology and potential for perimenopause. Facts, Views & Vision in ObGyn. 2011;3(2):109–120. https://pmc.ncbi.nlm.nih.gov/articles/PMC3987489/

Frequently asked questions

What’s the difference between progesterone and progestin?

Bioidentical progesterone is chemically identical to the hormone your body makes. Progestins are synthetic compounds that can mimic some of its effects but may cause side effects like bloating, mood changes, or breast tenderness.

Is progesterone therapy safe?

When prescribed and monitored by a qualified provider, bioidentical progesterone is safe and effective. It follows established clinical guidelines and is often used long-term for symptom relief and health maintenance.

Can progesterone help with anxiety and sleep?

Yes. Progesterone activates calming brain receptors and promotes natural sleep cycles, helping reduce anxiety and restlessness.

Do I need progesterone if I’m already taking estrogen?

In most cases, yes. Progesterone protects the uterine lining from unopposed estrogen and supports overall hormonal stability. Your provider will determine the ideal combination.

How long before I feel results?

Most women notice improvement in sleep and calmness within 2–4 weeks, with continued benefits building over several months.